What is GlucosaGuard® Equine?
GlucosaGuard® Equine is a proven joint health supplement. It is 100% pure glucosamine hydrochloride, a highly stable salt of glucosamine. Glucosamine is an amino sugar (a sugar molecule with an amino group attached) and is found naturally in the bodies of all animals.
GlucosaGuard® Equine is the highest quality glucosamine hydrochloride (United States Pharmacopial specifications). The hydrochloride salt provides considerably more glucosamine per unit weight of salt than the sulfate salt as it comprises 83% glucosamine compared to 59% glucosamine for the sulfate salt.
GlucosaGuard® Equine is a convenient and easy to use powder that you add to your horse's food.
What is osteoarthritis?
Osteoarthritis is an inflammatory disease characterised by progressive and permanent break down of cartilage in joints. Animals with arthritis suffer pain which is manifest as lameness and stiffness.
Like all tissues in the body, cartilage undergoes constant repair. Cartilage has a huge capacity to synthesise its major components (proteoglycans and collagen). In a normal healthy joint, the amount of cartilage matrix that breaks down during normal daily activity and the amount of new cartilage that is produced to replace the degraded cartilage are the same, but in osteoarthritis cartilage breakdown exceeds cartilage synthesis.
Benefits of glucosamine in osteoarthritis
In studies in animals (dogs and horses) and humans with osteoarthritis, oral administration of glucosamine has been found to have beneficial effects which include relieving the pain and inflammation of osteoarthritis and reducing the narrowing of the joint space that occurs in osteoarthritis, with a resultant improvement in mobility.
The glucosamine hydrochloride and glucosamine sulfate salts have generally been found to have comparable effects per unit dose (weight) of glucosamine.
How glucosamine works in osteoarthritis
Glucosamine is a fundamental building block of cartilage, providing important raw materials for the synthesis of cartilage proteoglycans. However, the action of glucosamine appears to extend beyond simply the provision of raw materials. Thus, there are also other mechanisms, mostly at the molecular level (such as effects on genes and chemicals within the body) by which glucosamine stimulates cartilage synthesis and more importantly, inhibits its breakdown, as well as inhibits the inflammatory process.
In in vitro studies, glucosamine has also been shown to inhibit the synthesis and activity of enzymes that degrade cartilage (most notably, the matrix metalloproteinases and aggrecanases), inhibit chemicals that mediate inflammation (most notably, prostaglandin E2 (PGE2) and nitric oxide) and inhibit the activity of other molecules such as nuclear factor kappa B (NFкB) and mitogen activated protein kinases (MAPK) that play a key role in the inflammatory process. The overall effect is to increase the synthesis and reduce the degradation of proteoglycans, and to reduce inflammation.
How safe is glucosamine?
Glucosamine is safe and non-toxic, giving you peace of mind when using GlucosaGuard® Equine. Results of clinical trials indicate a good safety profile for glucosamine in all species tested (humans, horses and dogs).
GlucosaGuard® Equine is a natural alternative to the non-steroidal anti-inflammatory drugs (NSAIDS) and is not associated with the side effects of these drugs.
When is treatment with glucosamine most effective?
GlucosaGuard® Equine is best as a:
(i) prophylactic management strategy to protect joint cartilage in horses at risk of developing joint problems including highly active horses and ageing horses – prevention is better than cure!
(ii) therapeutic for horses with existing mild, low-grade osteoarthritis. Using GlucosaGuard® Equine early on in disease is likely to give the greatest effect.
GlucosaGuard® Equine is designed for regular, longer-term, cost-effective, low dose administration. GlucosaGuard® Equine assists in keeping your horse active, flexible, mobile and pain free.